The main advantage of genomic matrices in the detection of structural aberrations is that they can provide information on thousands of targets in a single experiment that can resolve any change in the number of copies, from the level of gene, chromosome to genome. Typically, a high number of probes in the coding region of genes supported by skeletal probes in the non-coding regions allows the detection of not only previously described, but also new alterations in regions of interest.

 

The CGH Arrangement allows us to quickly and efficiently determine the relative abundance of nucleic acid sequences in the target sample. The method uses a large number of short stretches of synthetic DNA that probe several genomic loci scattered throughout the genome. The target DNA sample is labeled and hybridized with the DNA probes located on a solid matrix surface. Based on the relative amount of the probe hybridized to each target point, information is obtained on the abundance of specific nucleic acid sequences within the sample.